Publications
2021
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Korstanje, R., Peters LL., Krasinski SD., Churchill GA.
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging.
Geroscience. 2021 Jul 23;. doi: 10.1007/s11357-021-00421-2. [Epub ahead of print] PubMed PMID: 34297313
[ Pubmed ] [full text] -
Young K, Eudy E., R Bella, Loberg M, Stearns T., Devyani S, Velten L, Haas S., Filippi, M., Trowbidge, J.
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging
Cell Stem Cell. 2021 Aug 5;28(8):1473-1482.e7. doi: 10.1016/j.stem.2021.03.017. Epub 2021 Apr 12.
[ Pubmed ] [full text] -
Takemon Y., Chick JM., Gerdes Gyuricza I, Selley DA, Devuyst O. Gygi SP., Churchill GA., Korstanje R.
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidey
Elife. 2021 Mar 9;10:e62585. doi: 10.7554/eLife.62585.
[ Pubmed ] [full text]
2020
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Khokhar ES, Borikar S, Eudy E, Stearns T, Young K, Trowbridge JJ
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.
Exp Hematol. 2020 Feb;82:43-52.e4. doi: 10.1016/j.exphem.2020.01.014. Epub 2020 Feb 1
[ Pubmed ] [full text] -
Ouellette AR, Neuner SM, Dumitrescu L, Anderson LC, Gatti DM, Mahoney ER, Bubier JA, Churchill G, Peters L, Huentelman MJ, Herskowitz JH, Yang HS, Smith AN, Reitz C, Kunkle BW, White CC, De Jager PL, Schneider JA, Bennett DA, Seyfried NT; Alzheimer’s Disease Genetics Consortium, Chesler EJ, Hadad N, Hohman TJ, Kaczorowski CC
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia
Cell Rep. 2020 Sep 1;32(9):108091. doi: 10.1016/j.celrep.2020.108091
[ Pubmed ] [full text] -
Rong Yuan, CJM Musters, Yun Zhu, Tracy R. Evans, Yujie Sun, Elissa Chesler, Luanne Peters, David E Harrison, Andrzej Bartke
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex specific manner in mice
Aging Cell. 2020 Oct 26;e13263. doi: 10.1111/acel.13263
[ Pubmed ] [full text] -
Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein
Rapamycin rejuvenates oral health in aging mice
eLife 2020;9:e54318 doi: 10.7554/eLife.54318
[ Pubmed ] [full text] -
Garrett MR, Korstanje R.
Using Genetic and Species Diversity to Tackle Kidney Disease.
Trends Genet. 2020 Jul;36(7):499-509. doi: 10.1016/j.tig.2020.04.001. Epub 2020 Apr 30.
[ Pubmed ] [full text]
2019
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Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
Geroscience. 2019 Dec 6. doi: 10.1007/s11357-019-00120-z
[ Pubmed ] [full text] -
Bubier JA, Sutphin GL, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, Langston MA, Chesler EJ
Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species
PLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523 PMID: PMC6461221
[ Pubmed ] [full text] -
Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR
Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass
PLoS Genet. 2019 May 1;15(5):e1008123. doi: 10.1371/journal.pgen.1008123. eCollection 2019 May. PMID: 31042701
[ Pubmed ] [full text] -
Alghamdi SM, Sundberg BA, Sundberg JP, Schofield PN, Hoehndorf R.
Quantitative evaluation of Ontology design patterns for combining pathology and anatomy ontologies
Sci Rep. 2019 Mar 11;9(1):4025. doi:10.1038/s41598-019-40368-1. PMID: 30858527
[ Pubmed ] [full text] -
Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ.
Sequencially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
Leukemia. 2019 Jan 28. doi: 10.1038/s41375-018-0368-6. [Epub ahead of print]
[ Pubmed ] [full text] -
Schmitt EE, Johnson EC, Yusifova M, Bruns DR.
The renal molecular clock: broken by aging restored by exercise
Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1087-F1093. doi: 10.1152/ajprenal.00301.2019. Epub 2019 Aug 28.
[ Pubmed ] [full text]
2018
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Thompson MJ, Chwiałkowska K, Rubbi L, Lusis AJ, Davis RC, Srivastava A, Korstanje R, Churchill GA, Horvath S, Pellegrini M
A Multi-tissue full lifespan epigenetic clock for mice
Aging (Albany NY). 2018 Oct 21;10(10):2832-2854. doi: 10.18632/aging.101590. PMID:30348905
[ Pubmed ] [full text] -
Backer G, Eddy S, Sheehan SM, Takemon Y, Reznichenko A, Savage HS, Kretzler M, Kostanje R
FAR2 is Associated with Kidney Disease in Mice and Humans
Physiologenomics. 2018 Apr 13 doi:1152/physiolgenomics.00118.2017
[ Pubmed ] [PMCID 29652635]
2017
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Lee BP, Curic I, George-Pandeth A, Flurkey K, Harrison DE, Yan R, Peters LL, Kuchel GA, Melzer D, Harries LW
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice
Sci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620
[PMCID PMC5356331] [full text] -
Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Merus JBJ, Murabito JM, Johnson AD, Korstanje R, Cohorts for Heart & Aging Research in Genomic Epidemiology Consortium Gene Expression Working Group
Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity
Aging Cell, 2017 Aug;16(4):672-682. doi: 10.1111/acel.12595.
[ PMCID PMC5506438 ] [full text] -
Tyler AL, Ji B, Gatti DM, Munger SC, Churchill GA, Svenson KL, Carter GW
Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice
Genetics. 2017 Jun;206(2):621-639. doi: 10.1534/genetics.116.198051
[ PMCID: PMC5499176 ] 7 Citations [full text]
2016
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Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ
Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span
J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223
[PMCID:PMC4707687] [full text]
[ Epub 2014 Dec 22 ] -
Korstanje R, Deutsch K, Balanos-Palmieri P, Hanke N, Schroder, P, Staggs L, Brasen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria
J Am Soc Nephrol. 2016 Nov;27(11):3271-3277
[ PMCID: PMC5084883 ] [full text] -
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans
Aging Cell. 2016 Jun 30. doi: 10.1111/acel.12499
[ Pubmed ] [Epub ahead of print] -
Sutphin GL, Mahoney JM, Sheppard K, Walton DO, Korstanje R
WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning
PLoS Comput Biol. 2016 Nov 3;12(11):e1005182. doi: 10.1371/journal.pcbi.1005182.
[ PMCID: PMS5094675 ] [full text] -
Young K, Borikar S, Bell R, Kuffler L, Phillip V, Trowbridge JJ
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging
J Exp Med. 2016 Oct 17;213(11):2259-2267. Epub 2016 Oct 10.
[ PMCID: PMC5068232] [full text]
2015
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Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL
Aging Research Using Mouse Models
Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195
[PMCID: PMC4590775] [full text] -
Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R
Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo
Oncotarget. 2015 Nov 24;6(37):39714-24. doi: 10.18632/oncotarget.5356
[PMCID: PMC4741857] [ Full text ] -
Bogue MA, Churchill GA, Chesler EJ
Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database
Mamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6
[PMCID: PMC4602074] [full text] [ Epub 2015 Aug 19 ] -
Noordmans GA, Hillebrands JL, van Goor H, Korstanje R
A roadmap for the genetic analysis of renal aging
Aging Cell. 2015 Oct;14(5):725-33. doi: 10.1111/acel.12378
PMCID: PMC4568960 [full text [ Epub 2015 Jul 29 ] -
Reznichenko A, Korstanje R
The role of platelet-activating factor in mesangial pathophysiology
Am J Pathol. 2015 Apr;185(4):888-96. doi: 10.1016/j.ajpath.2014.11.025
PMCID: PMC4380849 [full text] [ Epub 2015 Feb 2 ] -
Yuan R, Gatti DM, Krier R, Malay E, Schultz D, Peters LL, Churchill GA, Harrison DE, Paigen B
Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1
J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):817-26. doi: 10.1093/gerona/glu114
PMCID: PMC4481683 [full text [ Epub 2014 Jul 28 ]
2014
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Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA
Quantitative trait locus mapping methods for diversity outbred mice
G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748
PMCID: PMC4169154 [full text] -
Gokhin DS, Dubuc EA, Lian KQ, Peters LL, Fowler VM
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
Front Physiol. 2014 Sep 29;5:375. doi: 10.3389/fphys.2014.00375
PMCID: PMC4178374 [full text] [ eCollection 2014 ] -
Grubb SC, Bult CJ, Bogue MA
Mouse phenome database
Nucleic Acids Res. 2014 Jan;42(Database issue):D825-34. doi: 10.1093/nar/gkt1159
PMCID: PMC3965087 [full text] [ Epub 2013 Nov 15 ] -
Huang Y, Caputo CR, Noordmans GA, Yazdani S, Monteiro LH, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands JL
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice
PLoS One. 2014 Mar 17;9(3):e91850. doi: 10.1371/journal.pone.0091850
PMCID: PMC3956762 [full text] [ eCollection 2014 ] -
Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching
Aging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226
PMCID: PMC4326954 [full text] [ Epub 2014 May 23 ] -
Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C;
Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains
Immunological Genome Consortium. J Immunol. 2014 Nov 1;193(9):4485-96. doi: 10.4049/jimmunol.1401280
PMCID: PMC4201955 [full text] [ Epub 2014 Sep 29 ] -
Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H
Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice
PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308
PMCID: PMC4213026 [full text] -
Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML
Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait
Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1296-307. doi: 10.1152/ajprenal.00074.2014
PMCID: PMC4042106 [full text][ Epub 2014 Apr 9 ]
2013
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Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ
High-precision genetic mapping of behavioral traits in the diversity outbred mouse population -
Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029
PMCID: PMC3709837 [full text] [ Epub 2013 Mar 20 ] -
Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H, Korstanje R
Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene
J Am Soc Nephrol. 2013 Dec;24(12):1995-2001. doi: 10.1681/ASN.2012080838
PMCID: PMC3839541 [full text] [ Epub 2013 Sep 5 ] -
Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070
PMCID: PMC3598361 [full text] [ Epub 2012 Mar 26 ] -
Yuan R, Flurkey K, Meng Q, Astle MC, Harrison DE
Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):27-35. doi: 10.1093/gerona/gls104
PMCID: PMC3598364 [full text] [ Epub 2012 May 8 ]
2012
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Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Bult CJ, Eppig JT, Sundberg JP
The Mouse Tumor Biology Database (MTB): a central electronic resource for locating and integrating mouse tumor pathology data
Vet Pathol. 2012 Jan;49(1):218-23. doi: 10.1177/0300985810395726
PMCID: PMC3130112 [full text] [ Epub 2011 Jan 31 ] -
Flurkey K, Yuan R
How the evolutionary theory of aging can guide us in the search for aging genes
Aging (Albany NY). 2012 May;4(5):318-9
PMCID: PMC3384432 [full text] [ No abstract available ] -
Kavirayani AM, Sundberg JP, Foreman O
Primary neoplasms of bones in mice: retrospective study and review of literature
Vet Pathol. 2012 Jan;49(1):182-205. doi: 10.1177/0300985811398252
PMCID: PMC3151475 [full text] [ Epub 2011 Feb 22 ] -
Li Q, Berndt A, Guo H, Sundberg JP, Uitto J
A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouse
Am J Pathol. 2012 Oct;181(4):1190-6. doi: 10.1016/j.ajpath.2012.06.014
PMCID: PMC3463623 [full text] [ Epub 2012 Jul 28 ] -
Maddatu TP, Grubb SC, Bult CJ, Bogue MA
Mouse Phenome Database (MPD)
Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. doi: 10.1093/nar/gkr1061
PMCID: PMC3245053 [full text] [ Epub 2011 Nov 18 ] -
Murabito JM, Yuan R, Lunetta KL
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
Gerontol A Biol Sci Med Sci. 2012 May;67(5):470-9. doi: 10.1093/gerona/gls089
PMCID: PMC3326242 [full text] -
Schofield PN, Vogel P, Gkoutos GV, Sundberg JP
Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice
Dis Model Mech. 2012 Jan;5(1):19-25. doi: 10.1242/dmm.008334
PMCID: PMC3255539 [full text] [ Epub 2011 Oct 25 ] -
Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B
Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. doi: 10.1073/pnas.1121113109
PMCID: PMC3361401 [full text] [ Epub 2012 May 7 ]
2011
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Lorenzo LP, Chen H, Shatynski KE, Clark S, Yuan R, Harrison DE, Yarowsky PJ, Williams MS
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress
Antioxid Redox Signal. 2011 Oct 15;15(8):2083-94. doi: 10.1089/ars.2010.3798
PMCID: PMC3166202 [full text] [ Epub 2011 Jun 15 ] -
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178
PMCID: PMC3021372 [full text] [ Epub 2010 Oct 25 ] -
Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV
New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models
Brief Funct Genomics. 2011 Sep;10(5):258-65. doi: 10.1093/bfgp/elr031
PMCID: PMC3189694 [full text] -
Sher RB, Cox GA, Mills KD, Sundberg JP
Rhabdomyosarcomas in aging A/J mice
PLoS One. 2011;6(8):e23498. doi: 10.1371/journal.pone.0023498
PMCID: PMC3154500 [full text] [ Epub 2011 Aug 10 ] -
Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R
Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation
Physiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010
PMCID: PMC3068516 [full text] [ Epub 2010 Dec 21 ] -
Won J, Marín de Evsikova C, Smith RS, Hicks WL, Edwards MM, Longo-Guess C, Li T, Naggert JK, Nishina PM
NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development
Hum Mol Genet. 2011 Feb 1;20(3):482-96. doi: 10.1093/hmg/ddq494
PMCID: PMC3016909 [full text] [ Epub 2010 Nov 15 ] -
Yuan R, Peters LL, Paigen B
Mice as a mammalian model for research on the genetics of aging
ILAR J. 2011;52(1):4-15
PMCID: PMC3074346 [full text]
2010
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Flurkey K, Astle CM, Harrison DE
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice
J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1275-84. doi: 10.1093/gerona/glq155
PMCID: PMC2990268 [full text] [ Epub 2010 Sep 5 ] -
Schofield PN, Gruenberger M, Sundberg JP
Pathbase and the MPATH ontology. Community resources for mouse histopathology
Vet Pathol. 2010 Nov;47(6):1016-20. doi: 10.1177/0300985810374845
PMCID: PMC3038412 [full text] [ Epub 2010 Jun 29 ] -
Sundberg JP, Schofield PN
Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbols
Vet Pathol. 2010 Nov;47(6):1100-4. doi: 10.1177/0300985810374837
PMCID: PMC3039125 [full text] [ Epub 2010 Aug 4 ]
2009
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Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
Aging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x
PMCID: PMC2768517 [full text] [ Epub 2009 Apr 9 ]