Research & Development Core

Core Leader: Ron Korstanje
Phone: 207-288-6992

Understanding the complexity of the aging process and its profound effects across all levels of biological organization will require a strong, interdisciplinary, and diverse supply of talented scientists. The overall goal of The Jackson Laboratory Nathan Shock Center (JAX NSC) Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research. During the current funding period, the JAX NSC Research Development Core competitively awarded funding and resources to aging projects across biological systems that resulted in new discoveries, research publications and sources of funding, and helped junior awardees to establish their own independent careers in aging research. Moving forward, these successes will be expanded by providing targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, will be leveraged to sustain and grow this foundation of researchers at JAX and within the aging community. The Specific Aims are: Aim 1. Fund projects for new investigators in aging research using a competitive pilot award program. Promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology. Aim 2. Provide resources to support pilot awardees and investigators new to aging research. Access to resources (e.g., aging mice, data, tissues, phenotype platforms, expertise) will be provided to support pilot awardees and other investigators new to aging research. The aging mouse cohorts and phenotyping technologies supported by the JAX NSC present a valuable opportunity for investigators to access material and collect data that might otherwise be prohibitively expensive or difficult to obtain. Aim 3. Provide mentorship and career development opportunities in aging research. Investigators new to aging research will be provided with mentorship by JAX NSC researchers and collaborators. They will also be given opportunities for career development in the aging field via support with the grant writing process, opportunities to participate in aging meetings, and introductions to potential collaborations within the broader aging community. The impact of the Research Development Core is that the pool of investigators devoted to the study of the basic biology of aging will be expanded.

The following are pilot project awardees since 2015.

2021 Pilot Project Awardees

Justin Crane, Ph.D., Assistant Professor, Northeastern University
Determining the efficacy of 4-PBA to reverse age-related muscle frailty

Cintia De Paiva, Ph.D., M.D., Associate Professor, Baylor College of Medicine
The Effect of Senescence on the Aged Lacrimal Gland and Heart

Karyn Frick, Ph.D., Professor, University of Wisconsin-Milwaukee
Effects of age, sex, and estradiol treatment on memory and affective function

Chiara Rolando, Ph.D., Assistant Professor, University of Milan
Investigate alterations in α-Synucleindistribution and α-Synuclein-tubulin interaction in different types of synaptic terminals during aging.

Jennifer Trowbridge, Ph.D. Associate Professor, The Jackson Laboratory
Evaluating age-associated clonal hematopoiesis in bone marrow

Amy Wagers, Ph.D., Professor, Harvard Medical School
Cisd2 gene transfer as a potential rejuvenation therapy in aged mice

Ashley Webb, Ph.D., Assistant Professor, Brown University
Investigate how genetic diversity affects the decline in neurogenesis in healthy aging

2020 Pilot Project Awardees

Erik Bloss, Ph.D., Assistant Professor, The Jackson Laboratory
Investigate the neuroanatomical targets for subsequent genetic or molecular manipulations aimed at arresting or reversing aging-related cognitive decline

Kataryzna Cieslik, Ph.D., Associate Professor, Baylor College of Medicine
Examine the proteome changes in the young and aged cardiac fibroblasts

George Sutphin, Ph.D., Assistant Professor, University of Arizona
Evaluate the efficacy of 3HAA at extending healthy lifespan in mice.

Jennifer Trowbridge, Ph.D. Associate Professor, The Jackson Laboratory
Aim 1: Test the hypothesis that there is a negative correlation between myeloid-biased hematopoiesis and estrogen levels in middle-aged female mice.
Aim2: Test the hypothesis that restoring estrogen in middle-aged female mice rejuvenates lineage-balanced hematopoiesis

Christopher Wiley, Ph.D., Assistant Professor, Buck Institute for Research on Aging
In vivo assessment of a polyunsaturated fatty acid that kills senescent cells

2019 Pilot Project Awardees:

Scott Leiser, Ph.D., University of Michigan
Determine the effect of mianserin supplementation at mid-life on aging

Chia Shan Wu, Ph.D., Texas A&M
Effects of dietary soluble fiber supplementation on fecal microbiome and metabolome in aging mice

Rupa Sridharan, Ph.D., University of Wisconsin
Determining the epigenetic determinants of cellular aging

Melissa Duncan, Ph.D., University of Delaware
Validate RNA seq results comparing the response of aged and young mice to cataract surgery

Vivek Kumar, Ph.D., The Jackson Laboratory
Video Analysis of gait in aged mice

David Baglietto-Vargas, Ph.D., University of California, Irvine
Age-associated changes in the white adipose cells

Cintia de Paiva, M.D., Ph.D., Baylor College of Medicine
Identifying Age-Related Changes in Molecular Signatures in Aged T Regulatory Cells

Katherine Aird, Ph.D., Penn State
Investigating the Aging Micro environment on Ovarian Cancer Biology

Chung-Ping Liao, Ph.D., UT Southwestern
The mechanism of aging-induced hair graying and hair loss in mammals

2018 Pilot Project Awardees:

Danitza Nebor, Ph.D. The Jackson Laboratory
Investigate whether decreasing of mTORC1 activity would increase the expression of the mouse bh1

Matt Kaeberlein, Ph.D. University of Washington
Examine and compare the effects of in-chow of 42mg/kg/day of rapamycin (42 ppm eRAPA) for 8 weeks (~2 months) on age-associated periodontal disease in wild-type C57BL/6 mice at 20 months of age.

Steven Gygi, Ph.D., Harvard University
The aged mouse proteome

Margarita Meer, Ph.D., Harvard University
Development of a blood-based DNA methylation clock in mice

Berenice Benayoun, Ph.D., University of Southern California
Sex dimorphism in aging macrophages

Danielle Bruns Ph.D./Emily Schmitt, Ph.D., University of Wyoming
Linking Cardiac Aging with Biological Clock Activity

Aby Buchwalter, Ph.D., University of California San Francisco
Quantify nucleor size as a proxy for nucleolar activity over age in tissue sections at 6, 12 and 18 months

Shohana Yakar, Ph.D. NYU
Test the effect of Methylene Blue on bone quality during Aging

Samual Beck, Ph.D., Mount Desert Island Biological Laboratory
CpG islands and chromatin architecture changes during aging

Giovanni Mann, Ph.D., King’s College London
Impact of ageing on endothelial cell trafficking of intermediate conductance Ca2+ activated potassium channels

2017 Pilot Project Grantees:

Muneer Hasham, Ph.D.,The Jackson Laboratory
Determining the genetic variations that impact the age-related B-cell immune response.

Duygu Ucar, Ph.D., The Jackson Laboratory
Epigenomic disruption of immune cell functions with aging in CC founder strains

Catherine Kaczorowski, Ph.D.,The Jackson Laboratory
Systems Genetics of Normal Aging and Alzheimer’s Disease.

Ewelina Bolcun-filas, Ph.D.,The Jackson Laboratory
Genetics and Genomics of the Ovarian Reserve and Female Fertility

Olga Anczukow, Ph.D.,The Jackson Laboratory
Identifying age-related changes in splicing regulation in the mammary gland

John Fryer, Ph.D., Mayo Clinic
Use single-cell RNAseq technology to determine the cellular response in all cell types in the aging brain.

2015/2016 Pilot Project Grantees:

Brett Kaufman, Ph.D., University of Pittsburg
Genetic Control of Mitochondrial DNA content with Aging

Gareth Howell, Ph.D., The Jackson Laboratory
Investigating the role of APOE in age-related neurovascular unit decline and neuroinflammation.