Research & Development Core

Core Leader: Ron Korstanje
Phone: 207-288-6992

The overall goal of JAX NSC Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research.

We provide targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, is leveraged to sustain and grow this foundation of researchers at JAX and within the aging community.

Our primary mechanism is the Pilot Award Program where promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology.

Since 2017, we have offered an in-kind program where the awardee envisions the study, but we perform the experiments for the awardee, collecting data and/or tissues. The awardee then uses these data and tissues for further analysis at his/her own institute. Using this innovative format, we can perform many more experiments for a larger number of investigators within the same budget.

Number of pilot projects performed since 2017. As the size of the experiments (number of animals) has been going up in the last few years, the number of projects we have been able to perform has slightly decreased.

Year External Investigators JAX Investigators Total
2017 1 5 6
2018 9 1 10
2019 6 2 8
2020 8 3 11
2021 6 1 7
2022 6 1 7
2023 5 1 6

2023 Pilot Project Awardees

Xu Zhang, Ph.D., Mayo Clinic
Preclinical testing of a senolytic drug

Ryo Higuchi-Sanabria, Ph.D., St. Jude Children’s Research Hospital
More than a loading control: form and function of actin during aging

Katherine Wert, Ph.D., St. Jude Children’s Research Hospital
Understanding Human Retinal Development and Cellular Changes during Disease

Jason Vevea, Ph.D., St.Jude Children’s Research Hospital
Investigating the normal age and sex dependent molecular changes of synaptic vesicles (SVs) and post-synaptic densities (PSDs) from brains of male, female, and female mice that mimic menopause

Denis Mogilenko, Ph.D., Vanderbilt University
Understanding dendritic cells as a driver of immune dysfunction in aging

Julia Oh, Ph.D., The Jackson Laboratory
Microbial modulation of aging associated kidney acidosis

2022 Pilot Project Awardees

Xu Zhang, Ph.D., Mayo Clinic
Preclinical testing of a senolytic drug to counter skeletal muscle aging

Michael Lustgarten, Ph.D., USDA Human Nutrition Research Center on Aging
Impact of a high-soluble fiber diet on the gut-muscle axis in aged mice

Sarah Mitchell, Ph.D., ETH Zürich / Healthy Aging Laboratory

Cintia De Paiva, Ph.D., M.D., Associate Professor, Baylor College of Medicine
Investigating sex-differences in the Lacrimal Gland Immune Infiltrates in Aged Diversity Outbred Mice

Brittany Angerola, Ph.D., The Jackson Laboratory for Genomic Medicine
Transcriptomic and cellular programs during aging and in breast cancer

Liisa Kuhn, Ph.D., University of Connecticut Health Center
Quantifying Senescence in Mouse Mandibles

George Sutphin, Ph.D., Assistant Professor, University of Arizona
Evaluate the efficacy of 3HAA at extending healthy lifespan in mice (expansion).

2021 Pilot Project Awardees

Justin Crane, Ph.D., Assistant Professor, Northeastern University
Determining the efficacy of 4-PBA to reverse age-related muscle frailty

Cintia De Paiva, Ph.D., M.D., Associate Professor, Baylor College of Medicine
The Effect of Senescence on the Aged Lacrimal Gland and Heart

Karyn Frick, Ph.D., Professor, University of Wisconsin-Milwaukee
Effects of age, sex, and estradiol treatment on memory and affective function

Chiara Rolando, Ph.D., Assistant Professor, University of Milan
Investigate alterations in α-Synucleindistribution and α-Synuclein-tubulin interaction in different types of synaptic terminals during aging.

Jennifer Trowbridge, Ph.D. Associate Professor, The Jackson Laboratory
Evaluating age-associated clonal hematopoiesis in bone marrow

Amy Wagers, Ph.D., Professor, Harvard Medical School
Cisd2 gene transfer as a potential rejuvenation therapy in aged mice

Ashley Webb, Ph.D., Assistant Professor, Brown University
Investigate how genetic diversity affects the decline in neurogenesis in healthy aging

2020 Pilot Project Awardees

Erik Bloss, Ph.D., Assistant Professor, The Jackson Laboratory
Investigate the neuroanatomical targets for subsequent genetic or molecular manipulations aimed at arresting or reversing aging-related cognitive decline

Kataryzna Cieslik, Ph.D., Associate Professor, Baylor College of Medicine
Examine the proteome changes in the young and aged cardiac fibroblasts

George Sutphin, Ph.D., Assistant Professor, University of Arizona
Evaluate the efficacy of 3HAA at extending healthy lifespan in mice.

Jennifer Trowbridge, Ph.D. Associate Professor, The Jackson Laboratory
Aim 1: Test the hypothesis that there is a negative correlation between myeloid-biased hematopoiesis and estrogen levels in middle-aged female mice.
Aim2: Test the hypothesis that restoring estrogen in middle-aged female mice rejuvenates lineage-balanced hematopoiesis

Christopher Wiley, Ph.D., Assistant Professor, Buck Institute for Research on Aging
In vivo assessment of a polyunsaturated fatty acid that kills senescent cells

2019 Pilot Project Awardees

Scott Leiser, Ph.D., University of Michigan
Determine the effect of mianserin supplementation at mid-life on aging

Chia Shan Wu, Ph.D., Texas A&M
Effects of dietary soluble fiber supplementation on fecal microbiome and metabolome in aging mice

Rupa Sridharan, Ph.D., University of Wisconsin
Determining the epigenetic determinants of cellular aging

Melissa Duncan, Ph.D., University of Delaware
Validate RNA seq results comparing the response of aged and young mice to cataract surgery

Vivek Kumar, Ph.D., The Jackson Laboratory
Video Analysis of gait in aged mice

David Baglietto-Vargas, Ph.D., University of California, Irvine
Age-associated changes in the white adipose cells

Cintia de Paiva, M.D., Ph.D., Baylor College of Medicine
Identifying Age-Related Changes in Molecular Signatures in Aged T Regulatory Cells

Katherine Aird, Ph.D., Penn State
Investigating the Aging Micro environment on Ovarian Cancer Biology

Chung-Ping Liao, Ph.D., UT Southwestern
The mechanism of aging-induced hair graying and hair loss in mammals

2018 Pilot Project Awardees

Danitza Nebor, Ph.D. The Jackson Laboratory
Investigate whether decreasing of mTORC1 activity would increase the expression of the mouse bh1

Matt Kaeberlein, Ph.D. University of Washington
Examine and compare the effects of in-chow of 42mg/kg/day of rapamycin (42 ppm eRAPA) for 8 weeks (~2 months) on age-associated periodontal disease in wild-type C57BL/6 mice at 20 months of age.

Steven Gygi, Ph.D., Harvard University
The aged mouse proteome

Margarita Meer, Ph.D., Harvard University
Development of a blood-based DNA methylation clock in mice

Berenice Benayoun, Ph.D., University of Southern California
Sex dimorphism in aging macrophages

Danielle Bruns Ph.D./Emily Schmitt, Ph.D., University of Wyoming
Linking Cardiac Aging with Biological Clock Activity

Aby Buchwalter, Ph.D., University of California San Francisco
Quantify nucleor size as a proxy for nucleolar activity over age in tissue sections at 6, 12 and 18 months

Shohana Yakar, Ph.D. NYU
Test the effect of Methylene Blue on bone quality during Aging

Samual Beck, Ph.D., Mount Desert Island Biological Laboratory
CpG islands and chromatin architecture changes during aging

Giovanni Mann, Ph.D., King’s College London
Impact of ageing on endothelial cell trafficking of intermediate conductance Ca2+ activated potassium channels

2017 Pilot Project Awardees

Muneer Hasham, Ph.D.,The Jackson Laboratory
Determining the genetic variations that impact the age-related B-cell immune response.

Duygu Ucar, Ph.D., The Jackson Laboratory
Epigenomic disruption of immune cell functions with aging in CC founder strains

Catherine Kaczorowski, Ph.D.,The Jackson Laboratory
Systems Genetics of Normal Aging and Alzheimer’s Disease.

Ewelina Bolcun-filas, Ph.D.,The Jackson Laboratory
Genetics and Genomics of the Ovarian Reserve and Female Fertility

Olga Anczukow, Ph.D.,The Jackson Laboratory
Identifying age-related changes in splicing regulation in the mammary gland

John Fryer, Ph.D., Mayo Clinic
Use single-cell RNAseq technology to determine the cellular response in all cell types in the aging brain.

2015/2016 Pilot Project Awardees

Brett Kaufman, Ph.D., University of Pittsburg
Genetic Control of Mitochondrial DNA content with Aging

Gareth Howell, Ph.D., The Jackson Laboratory
Investigating the role of APOE in age-related neurovascular unit decline and neuroinflammation.